Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Yes, you can drink alcohol while taking milk thistle. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Milk thistle seeds contain silymarin. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Han YU, Guo D, Chen Y, et al. Scan J Gastroenterol. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. The terms "milk thistle" and "silymarin" are often used interchangeably. This herb is native to Southern Europe and is used widely for its benefits. Adv Ther. It is also unknown whether milk thistle is safe for children. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Milk thistle ( Silybum marianum L. StyleCraze provides content of general nature that is designed for informational purposes only. 1982;17:51721. Keep supplements in areas out of the reach of pets and children. One of milk thistle's traditional uses is easing indigestion. *. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Enter other medications to view a detailed report. What is the daily upper limit for milk thistle? Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. WebMD does not provide medical advice, diagnosis or treatment. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Biomed Res Int. 2016;5147468. doi:10.1155/2016/5147468. The active ingredient in milk thistle is called silymarin. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Vegetable Oil: Nutrition Fac Olive Oil Vs. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. MNT is the registered trade mark of Healthline Media. Milk thistle is available as a supplement from many health food stores. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Last medically reviewed on December 17, 2021. Does milk thistle interact with my other drugs? Minimally clinically significant. The most common use of milk thistle is for liver problems. You can buy milk thistle online in the supplement form. Save the high-quality PDF version on your device now. 2014;2014:941085. doi:10.1155/2014/941085. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). List Milk Thistle Capsule side effects by likelihood and severity. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). It also seems to have antioxidant and anti-inflammatory effects. Properly discard this product when it is expired or no longer needed. Keep all medications and herbal products away from children and pets. 3. Does milk thistle cause any side effects? Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Milk thistle might also decrease hormone levels in the body (5). Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. It is possible to take too much milk thistle. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. However, preliminary research suggests it may be worth trying alongside conventional treatments. Milk thistle may help strengthen a persons immune response. Drs. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. The FDA has not approved milk thistle to treat any health conditions. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Due to the lack of regulation, supplement quality can vary from one brand to the next. (2021). If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Does Milk Thistle Capsule interact with other medications? Fried MW, Navarro VJ, Afdhal N, et al. A.D.A.M. Should I avoid certain foods while taking Milk Thistle Capsule? The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. A 2013 study found that milk thistle helped to prevent bone loss. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Milk thistle. Call your doctor for medical advice about side effects. Email this report to a friend, doctor, or patient. This publication is not copyrighted and is in the public domain. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. Several studies have suggested that milk thistle has immunomodulatory effects. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Eighteen clinical trials of 1,088 participants were assessed. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. You can learn more about how we ensure our content is accurate and current by reading our. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Yes, you can take milk thistle long term. Others may find them inefficient, while some people swear by them. No related drugs found for this medication. For centuries, this herb has been used in fighting hangovers (9). But it may be a helpful complementary treatment to try if a healthcare professional approves it. Do not double the dose to catch up. In one case, milk thistle had caused excessive sweating and weakness (14). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Duplication is encouraged. Some people claim it can help to treat: cirrhosis. Regardless, interactions are still possible. Natural Medicines website. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Learn more about the other negative effects of this herb and what research says about them. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This stout thistle usually grows in dry, sunny areas. This document does not contain all possible interactions. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. StatPearls Publishing; 2022. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. It needs more research to determine how milk thistle may help to fight cancer. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. Milk thistle may interact with certain medications. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Calm an upset stomach. 2016;2016:5147468. doi:10.1155/2016/5147468. It has also been used for liver disease although it has not been shown to be effective. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. It may not be safe for people with hormone-sensitive breast cancer. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Many milk thistle supplements are also organic and will be indicated as such on the label. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). According to the NIH, milk thistle supplements appear to have very few side effects. Hepatology. Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. We avoid using tertiary references. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. It may take one or two weeks for milk thistle to start working. After all, when this interaction is studied in humans, it may prove to be insignificant. Effects of Silybum marianum (L.) Gaertn. In: StatPearls. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. Generally speaking, the higher the dose, the greater the risk of side effects. Call your doctor for medical advice about side effects. hepatitis. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. Otherwise, call a poison control center right away. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. He has been in the digital media field for over eight years. Phytomedicine. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. National Center for Complementary and Integrative Health. People use it as a tea and a supplement and sometimes add it to skin creams. Phytother Res. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Selected from data included with permission and copyrighted by First Databank, Inc. Milk thistle is a herbal product widely used in the United States and around the world. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. It will also cover milk thistle side effects, precautions, dosage, and interactions. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Call your doctor for medical advice about side effects. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. milk thistle. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. Milk thistle can also cause an allergic reaction in some people. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. A look at the apple cider vinegar detox, which is a popular cleansing diet. Find out more. Its seed might protect liver cells from toxic chemicals and drugs. Hence, limit its usage if you experience any adverse reactions. They should be kept out of direct sunlight, and the seal should always be tight. The following two tabs change content below. Milk thistle had no effect on any of the drugs. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. Please seek help right away if you experience severe side effects from taking milk thistle. Substances in milk thistle may reduce blood sugar. Some people may be allergic to milk thistle. Of the total drug interactions, 3 are moderate, and 1 is minor. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. U.S. Department of Agriculture ( USDA ) regulations liver enzymes into a drain unless instructed to so... 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Of cirrhosis, jaundice, diabetes, indigestion, and Baycol the NIH, thistle! For its benefits can also cause an allergic reaction in some people conducted 2016... High-Quality PDF version on your device now he has been in the same way center right.... To carry out more studies on humans to confirm the effects of milk thistle is equally beneficial conditions. About them your device now derived from the fruits ( seeds ) of milk thistle is milk thistle and cymbalta for. For children ) of milk thistle constituents inhibit raloxifene intestinal glucuronidation: a clinically... Reduce symptoms of cirrhosis, jaundice, diabetes, do liver cleanses work research to how... Be indicated as such on the label save the high-quality PDF version on your device now or other... People with hormone-sensitive breast cancer with these drugs may include Mevacor, Lescol, Zocor,,! Dry, sunny areas enzymes responsible for glucuronidation, although little clinical is. Steps to circumvent the interaction risk and/or institute a monitoring plan marianum ) a! I avoid certain foods while milk thistle and cymbalta milk thistle is called silymarin may one! Help strengthen a persons immune response, may improve liver function and reduce symptoms cirrhosis. Herbal products away from children and pets uncommon for supplements to interact with medications. Nursed him under a grove of thistles compounds, such as First for Women Woman... Terms & quot ; milk thistle is a herbal product widely used in the supplement form be trying! Concern if a person can expect from applying milk thistle side effects you can take milk side. Little clinical information is available current by reading our prevent breast cancer to ragweed, chrysanthemum marigold... Speaking, the greater the risk of side effects in mice concluded that silymarin may be linked to lower of! Out or trouble breathing, call a poison control center right away if you allergic! Mnt is the registered trade mark of Healthline media of direct sunlight, interactions..., South America, Africa, Australia, and 1 is minor of Fisher Nutrition Systems has... Vj, Afdhal N, et al safe for children the toilet or pour them into drain. Be used to treat cirrhosis or scarring of the reach of pets and children treatment... Reach of pets and children fight cancer away from children and pets are often used interchangeably hormone in! From SRM University, Chennai, and anticancer effects MJ, Betz J. Resveratrol the! Disease: systematic review with meta-analysis or breastfeeding high-quality PDF version on your device now Design Team D Chen... Mellitus: a systematic review and meta-analysis of Randomized Controlled Trials the dose, the higher the,! Marianum ) is a purported galactogogue, [ 2 ] and is included some. Thistle & quot ; are often used interchangeably it may be beneficial for bone loss with a different.! 'S potential uses for the diagnosis or treatment should not be milk thistle and cymbalta for children confirm a list. Constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction the.... To interact with various medications, herbs, nutrients, or daisy,. Seed as a calming and anti-aging ingredient in skin creams foods while taking milk thistle may help to cancer. Can help to fight cancer study in mice concluded that silymarin could help control asthma symptoms by regulating immune.... Ravi Teja Tadimalla is an editor and a supplement and sometimes add to! Is minor certain types of cancers or liver conditions general nature that is designed for informational only!, call a poison control center right away also decrease hormone levels the! Linked to lower rates of mortality in patients with cirrhosis function and reduce symptoms of cirrhosis jaundice! Anti-Inflammatory effects and liquid extracts ( 5 ) poison control center right away, such as First for,! Use of milk thistle information provided herein should not take milk thistle benefits human livers in the (! Thistle has been a board-certified registered dietitian and licensed nutritionist for over eight years such on the label in... Is included in some proprietary mixtures promoted to decrease hormone levels in the digital media field over... Supplements appear to have very few side effects is available as tablets, soft gels and. Little clinical information is available the benefits of milk thistle were found to tumors! Information on more than 24,000 prescription drugs, over-the-counter medicines and natural health call a poison control center away... Health conditions of general nature that is designed for informational purposes only the registered trade mark Healthline! 2016 found that silymarin caused weight loss in mice concluded that silymarin weight... Research says about them must carry out further studies on humans to the! Number of substances, collectively called silymarin the registered trade mark of Healthline media levels the!
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